{"id":758,"date":"2017-12-28T19:41:58","date_gmt":"2017-12-28T19:41:58","guid":{"rendered":"http:\/\/www.drshevchuk.com.ua\/?p=758"},"modified":"2017-12-28T19:41:58","modified_gmt":"2017-12-28T19:41:58","slug":"antibiotic-prophylaxis-to-prevent-surgical-site-infections-in-children-a-prospective-cohort-study-%d0%b0%d0%bd%d1%82%d0%b8%d0%b1%d1%96%d0%be%d1%82%d0%b8%d0%ba%d0%be%d0%bf%d1%80%d0%be%d1%84%d1%96","status":"publish","type":"post","link":"http:\/\/www.drshevchuk.com.ua\/?p=758","title":{"rendered":"Antibiotic Prophylaxis to Prevent Surgical Site Infections in Children: A Prospective Cohort Study\/ \u0410\u043d\u0442\u0438\u0431\u0456\u043e\u0442\u0438\u043a\u043e\u043f\u0440\u043e\u0444\u0456\u043b\u0430\u043a\u0442\u0438\u043a\u0430 \u0434\u043b\u044f \u043f\u043e\u043f\u0435\u0440\u0435\u0434\u0436\u0435\u043d\u043d\u044f \u0456\u043d\u0444\u0435\u043a\u0446\u0456\u0457 \u043e\u0431\u043b\u0430\u0441\u0442\u0456 \u0445\u0456\u0440\u0443\u0440\u0433\u0456\u0447\u043d\u043e\u0433\u043e \u0432\u0442\u0440\u0443\u0447\u0430\u043d\u043d\u044f \u0443 \u0434\u0456\u0442\u0435\u0439"},"content":{"rendered":"

Antibiotic Prophylaxis to Prevent Surgical Site Infections in Children: A Prospective Cohort Study<\/h1>\n
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Khoshbin, Amir MD, MSc*<\/sup>; So, Jeannette P. MSc\u2020<\/sup>; Aleem, Ilyas S. MD\u2021<\/sup>; Stephens, Derek MSc\u00a7<\/sup>; Matlow, Anne G. MD, MSc, FRCSC\u00b6<\/sup>; Wright, James G. MD, MPH, FRCSC*,\u2020,\u00a7<\/sup>for The SickKids Surgical Site Infection Task Force<\/p>\n<\/section>\n

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Annals of Surgery:\u00a0August 2015 – Volume 262 – Issue 2 – p 397\u2013402<\/a><\/span><\/div>\n
doi: 10.1097\/SLA.0000000000000938<\/div>\n<\/section>\n
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Abstract<\/h2>\n

Objective:\u00a0<\/span>To investigate the association between antibiotic prophylaxis (AP) and surgical-site infection in pediatric patients.<\/p>\n

Background:\u00a0<\/span>Surgical-site infections (SSIs) are a major cause of postoperative morbidity and mortality. Despite numerous studies in adults, benefit of AP in preventing SSIs in children is uncertain.<\/p>\n

Methods:\u00a0<\/span>Patients aged 0 to 21 years who underwent surgical procedures at a pediatric acute care hospital from April 1, 2009, to December 31, 2010, were assessed. Antibiotic prophylaxis indication and administration according to an evidence-based guideline were recorded. Complete compliance was defined as AP given, when indicated, within 60 minutes before incision. Surgical-site infections were identified using the Centers for Disease Control and Prevention criteria and documented in the medical records using the\u00a0International Classification of Diseases, Tenth Revision<\/em>. Multiple logistic regressions adjusting for age, sex, American Society of Anesthesiologists status, wound classification, admission status, surgical discipline, and surgical duration evaluated association of AP compliance and SSI.<\/p>\n

Results:\u00a0<\/span>Of 5309 patients for whom antibiotics were indicated, 3901 (73.5%) with complete compliance had an infection rate of 3.0%, whereas 1408 (26.5%) who were not compliant had an infection rate of 4.3% (adjusted relative risk: 0.7; 95% confidence interval: 0.5\u20130.9;\u00a0P<\/em>\u00a0= 0.02). Of 4156 patients for whom antibiotics were not indicated, the 895 (21.5%) who received antibiotics had an infection rate of 1.7% compared with 0.7% in the 3261 (78.5%) who did not receive antibiotics (adjusted relative risk: 1.6; 95% confidence interval: 0.8\u20133.1;\u00a0P<\/em>\u00a0= 0.18).<\/p>\n

Conclusions:\u00a0<\/span>In pediatric surgery, complete compliance with AP was associated with 30% decreased risk of SSI.<\/p>\n<\/div>\n<\/div>\n<\/section>\n

Copyright \u00a9 2015 Wolters Kluwer Health, Inc. All rights reserved.<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Antibiotic Prophylaxis to Prevent Surgical Site Infections in Children: A Prospective Cohort Study Khoshbin, Amir MD, MSc*; So, Jeannette P. MSc\u2020; Aleem, Ilyas S. MD\u2021; Stephens, Derek MSc\u00a7; Matlow, Anne G. MD, MSc, FRCSC\u00b6; Wright, James G. MD, MPH, FRCSC*,\u2020,\u00a7for The SickKids Surgical Site Infection Task Force Annals of Surgery:\u00a0August 2015 – Volume 262 – […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[9],"tags":[44,43],"_links":{"self":[{"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/posts\/758"}],"collection":[{"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=758"}],"version-history":[{"count":1,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/posts\/758\/revisions"}],"predecessor-version":[{"id":759,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=\/wp\/v2\/posts\/758\/revisions\/759"}],"wp:attachment":[{"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=758"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drshevchuk.com.ua\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}